Neuroprogesterone: Key to estrogen positive feedback?
نویسندگان
چکیده
منابع مشابه
Differential effects of aging on estrogen negative and positive feedback.
Recent studies have demonstrated an age-related decline in gonadotropins and a decrease in pituitary responsiveness to GnRH, indicating that aging influences the neuroendocrine components of the female reproductive axis independently of changes in ovarian function. To determine whether aging might also affect the luteinizing hormone (LH) negative and positive feedback responses to gonadal stero...
متن کاملDefinition of Estrogen Receptor Pathway Critical for Estrogen Positive Feedback to Gonadotropin-Releasing Hormone Neurons and Fertility
The mechanisms through which estrogen regulates gonadotropin-releasing hormone (GnRH) neurons to control mammalian ovulation are unknown. We found that estrogen positive feedback to generate the preovulatory gonadotropin surge was normal in estrogen receptor beta knockout (ERbeta) mutant mice, but absent in ERalpha mutant mice. An ERalpha-selective compound was sufficient to generate positive f...
متن کاملPositive feedback
Positive feedback is a process that occurs in a feedback loop in which the effects of a small disturbance on a system include an increase in the magnitude of the perturbation.[1] That is, A produces more of B which in turn produces more of A.[2] In contrast, a system in which the results of a change act to reduce or counteract it has negative feedback.[1][3] Mathematically, positive feedback is...
متن کاملThe Neurosteroid Progesterone Underlies Estrogen Positive Feedback of the LH Surge
Our understanding the steroid regulation of neural function has rapidly evolved in the past decades. Not long ago the prevailing thoughts were that peripheral steroid hormones carried information to the brain which passively responded to these steroids. These steroid actions were slow, taking hours to days to be realized because they regulated gene expression. Over the past three decades, disco...
متن کاملClassical estrogen receptor alpha signaling mediates negative and positive feedback on gonadotropin-releasing hormone neuron firing.
During the female reproductive cycle, the neuroendocrine action of estradiol switches from negative feedback to positive feedback to initiate the preovulatory GnRH and subsequent LH surges. Estrogen receptor-alpha (ERalpha) is required for both estradiol negative and positive feedback regulation of LH. ERalpha may signal through estrogen response elements (EREs) in DNA and/or via ERE-independen...
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ژورنال
عنوان ژورنال: Brain Research Reviews
سال: 2008
ISSN: 0165-0173
DOI: 10.1016/j.brainresrev.2007.06.009